Nicholas Tzikas, MD, MPHHeadache & Facial Pain Medicine

About

Headache is a symptom. Migraine is a complex neurological condition.

Headache medicine is a subspecialty, not a prescription. There are more than 200 distinct headache and facial pain disorders, and the diagnosis is rarely as simple as 'just a headache.'

Nicholas Tzikas, MD, MPH, headache and facial pain specialist
Nicholas Tzikas, MD, MPH
Director, Center of Interventional Headache Medicine

I am a headache and facial pain specialist. That is the entirety of my practice.

After serving as chief resident during residency training, I pursued fellowship training in headache and facial pain medicine under Dr. Stewart Tepper at Dartmouth-Hitchcock. I later joined the faculty at Yale School of Medicine, where I co-directed the Headache & Facial Pain Fellowship and led headache medicine programs at the Stamford and Greenwich sites.

My early training provided a broad foundation across medicine. Headache medicine taught me where to focus.

My clinical work has been devoted exclusively to headache and facial pain disorders. I have cared for patients with migraine, cluster headache, trigeminal neuralgia, occipital neuralgia, post-traumatic headache, and other complex headache conditions, while helping train the next generation of headache neurologists.

Most patients who find me have already seen several clinicians and tried many treatments. That experience is not a failure of prior care; it is usually the reason a focused, subspecialty evaluation is needed. My role is to add that layer of depth, working alongside the providers you have already seen.

My practice is devoted entirely to headache and facial pain.

Clinical perspective

Why headache medicine is more complex than it looks.

There are more than 200 distinct headache and facial pain disorders. Many of them look alike at first glance — throbbing, pressure, one-sided, behind the eye — but each has its own biology, triggers, and treatment logic. Telling them apart is the work.

Migraine is a hereditary neurological condition that travels in families. The same genetic wiring that can make the nervous system vigilant and adaptable can also make it hypersensitive: ordinary light, sound, hormones, sleep changes, or weather shifts become triggers that last for hours or days. It is not a personality flaw or a stress reaction; it is biology, passed across generations, that has become disabling rather than protective.

Headache can also be the first warning of another condition — a CSF pressure disorder, a vascular or inflammatory problem, a connective tissue disorder, or hormonal and sleep disorders. Recognizing when pain is a symptom of something else, and when it is the primary disorder itself, is what the subspecialty is built for.

The diagnosis usually lives in the details of the history.

From that history — the pattern, the family story, the prior workup, and the triggers that are easy to miss — a clearer picture usually emerges. The goal is not just to treat the pain, but to understand the system producing it.

Reviewing brain MRI and cerebral venous imaging on a diagnostic workstation
Imaging is reviewed directly, with a specific question in mind — pressure, veins, vessels, or structure.

Training & appointments

Academic Leadership

  1. Director, Center of Interventional Headache Medicine

    Present

    Interventional Neuro Associates, Long Island, New York

  2. Assistant Professor of Clinical Neurology

    2018–2026

    Yale School of Medicine, Department of Neurology

  3. Co-Director, Headache & Facial Pain Fellowship

    Yale School of Medicine

  4. Site Director, Headache Medicine

    Yale Stamford & Greenwich

Training

  1. Headache & Facial Pain Medicine Fellowship

    Dartmouth-Hitchcock Medical Center · Mentored by Dr. Stewart Tepper

  2. Chief Resident

    Hofstra Northwell School of Medicine

  3. Residency Training

    Hofstra Northwell School of Medicine

  4. Internship

    Dartmouth-Hitchcock Medical Center

Education

  1. MD, MPH

    St. George's University · Public Health Practicum, Columbia University

Academic & peer inquiries

Fellowship, teaching, research, and media.

For peer consultation, fellowship or teaching matters, research collaboration, or media requests, please write directly rather than through the clinical office.

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